Journal: Scientific Reports
Article Title: Circulating MicroRNA-92b-3p as a Novel Biomarker for Monitoring of Synovial Sarcoma
doi: 10.1038/s41598-017-12660-5
Figure Lengend Snippet: Differential diagnosis of synovial sarcoma from other soft tissue sarcomas by circulating/secreted miR-92b-3p . ( A , B ) The expression of miR-92b-3p and miR-150-3p in cells ( A ) and cell culture media ( B ) of SS (SYO-1, YaFuSS, HS-SY-II, and Yamato-SS) and the other STS cell lines (HT1080, NMS2, and UPS2023). The Mann-Whitney U test was used for comparison between groups. ( C ) Serum miR-92b-3p levels in SS patients and other STS patients ( p < 0.001). The Mann-Whitney U test was used for comparison between groups. ( D ) ROC curve analysis of miR-92b-3p discriminating SS patients from other STS patients. AUC was 0.88 (95% confidence interval = 0.72–1.0). ( E ) Serum miR-150-3p expression levels in SS patients and other STS patients. The Mann-Whitney U test was used for comparison between groups. ( F ) ROC curve analysis of miR-150-3p discriminating SS patients from other STS patients. AUC was 0.54 (95% confidence interval = 0.33–0.75).
Article Snippet: A human malignant peripheral nerve sheath tumour cell line NMS2 was available from the cell bank of RIKEN BioResource Center (Ibaraki, Japan).
Techniques: Biomarker Discovery, Expressing, Cell Culture, MANN-WHITNEY, Comparison